Melittin Inhibits Hypoxia-Induced Vasculogenic Mimicry Formation and Epithelial-Mesenchymal Transition through Suppression of HIF-1/Akt Pathway in Liver Cancer

Figure 4

The inhibitory effect of melittin on CoCl₂-induced EMT is mediated by Akt pathway. (a) Melittin inhibited CoCl₂-induced phosphorylation of Akt; (b) LY294002 inhibited CoCl₂-induced EMT; (c) SC-79 blocked the effect of melittin on CoCl₂-induced EMT; (d) activation of Akt reversed the effect of melittin on CoCl2-induced migration of SMMC-7721. Data are expressed as means ± S. (d) (N=6) P<0.01 compared with control group; P<0.01 compared with CoCl₂ group; P<0.01 compared with CoCl₂+melittin group.

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