Melittin Inhibits Hypoxia-Induced Vasculogenic Mimicry Formation and Epithelial-Mesenchymal Transition through Suppression of HIF-1/Akt Pathway in Liver Cancer

Figure 5

Melittin inhibits VM formation and HIF1-α expression in the xenografts in nude mice. (a) and (b) Melittin inhibited the tumor growth in vivo. Data are expressed as means ± S.D. (N=3). (c) The VM formation in the xenografts in nude mice determined by CD34 and PAS double staining. (d) Immunohistochemical staining of the HIF1-α expression in the xenografts in nude mice.

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