Evidence-Based Complementary and Alternative Medicine

Research Article

Liquid Chromatography-Mass Spectrometry-Based Plasma Metabolomics Study of the Effects of Moxibustion with Seed-Sized Moxa Cone on Hyperlipidemia

Table 1

Pathway terms for the differential metabolites in AMT vs BMT.


Pathway term	value	Metabolites in KEGG	Differential metabolites	FC

Pathogenic Escherichia coli infection	1.95E − 03	Phosphatidylethanolamine	PE(18:3(6Z, 9Z, 12Z)/P-18:1(11Z))	0.61
			PC(14:0/22:4(7Z, 10Z, 13Z, 16Z))	0.77
			PC(15:0/16:0)	1.12
			PC(18:0/P-18:0)	0.69

Glycerophospholipid metabolism	3.25E − 03	Phosphatidylcholine	PC(14:0/24:1(15Z))	0.64
			PC(16:0/P-18:0)	0.18
			PC(14:0/20:2(11Z, 14Z))	0.29
		Phosphatidylethanolamine	PE(18:3(6Z, 9Z, 12Z)/P-18:1(11Z))	0.61

Fatty acid biosynthesis	3.68E − 03	Palmitic acid	Palmitic acid	1.17
Fatty acid biosynthesis	3.68E − 03	Stearic acid	Stearic acid	1.15

Biosynthesis of unsaturated fatty acids	4.45E − 03	Palmitic acid	Palmitic acid	1.17
Biosynthesis of unsaturated fatty acids	4.45E − 03	Stearic acid	Stearic acid	1.15

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	5.85E − 03	Phosphatidylethanolamine	PE(18:3(6Z, 9Z, 12Z)/P-18:1(11Z))	0.61

Regulation of autophagy	9.73E − 03	Phosphatidylethanolamine	PE(18:3(6Z, 9Z, 12Z)/P-18:1(11Z))	0.61
Regulation of autophagy		3,4-Dihydroxymandelate	3,4-Dihydroxymandelic acid	0.73
Metabolic pathways		Palmitic acid	Palmitic acid	1.17
		Phosphatidylcholine	PC(14:0/22:4(7Z, 10Z, 13Z, 16Z))	0.77
			PC(15:0/16:0)	1.12
			PC(18:0/P-18:0)	0.69
			PC(14:0/24:1(15Z))	0.64
			PC(16:0/P-18:0)	0.18
			PC(14:0/20:2(11Z, 14Z))	0.29
		Phosphatidylethanolamine	PE(18:3(6Z, 9Z, 12Z)/P-18:1(11Z))	0.61
			TG(16:1(9Z)/16:1(9Z)/18:2(9Z, 12Z))	0.65
			TG(16:0/16:1(9Z)/18:2(9Z, 12Z))	0.57
		Triacylglycerol	TG(16:0/16:0/18:2(9Z, 12Z))	0.55
			TG(16:0/16:0/18:1(9Z))	0.52
			TG(16:0/18:0/18:2(9Z, 12Z))	0.56
			SM(d18:0/18:1(11Z))	0.72
		Sphingomyelin	SM(d18:0/22:1(13Z))	0.81
			SM(d18:0/22:0)	0.59
			SM(d18:0/18:1(11Z))	0.72

Sphingolipid metabolism	4.78E − 02	Sphingomyelin	SM(d18:0/22:1(13Z))	0.81
			SM(d18:0/22:0)	0.59
			PC(14:0/22:4(7Z, 10Z, 13Z, 16Z))	0.77
			PC(15:0/16:0)	1.12
			PC(18:0/P-18:0)	0.69

Linoleic acid metabolism	4.97E − 02	Phosphatidylcholine	PC(14:0/24:1(15Z))	0.64
			PC(16:0/P-18:0)	0.18
			PC(14:0/20:2(11Z, 14Z))	0.29

Fatty acid elongation in mitochondria	5.16E − 02	Palmitic acid	Palmitic acid	1.17

FC: fold change.