Research Article

Comparative Pharmacokinetics of Geniposidic Acid, Genipin-1-β-Gentiobioside, Geniposide, Genipin, and Crocetin in Rats after Oral Administration of Crude Gardeniae Fructus and Its Three Processed Products Using LC-MS/MS

Table 3

Recoveries and matrix effects of 5 compounds (n = 3).

CompoundsConcentration (ng/mL)RecoveryMatrix effect
Mean ± SD (%)RSD (%)Mean ± SD (%)RSD (%)

Geniposidic acid1096.7 ± 4.84.96114 ± 108.77
30110 ± 1311.82103 ± 109.71
300111 ± 65.41110 ± 43.64
300097.8 ± 4.14.19115 ± 21.74

Genipin-1-β-gentiobioside1097.2 ± 5.55.6692.5 ± 7.58.11
3094.7 ± 2.12.22114 ± 43.51
300100 ± 1212.0188.6 ± 5.76.43
300094.8 ± 4.14.3293.9 ± 4.75.01

Geniposide1097.4 ± 9.49.6597.3 ± 11.511.82
30110 ± 43.6496.4 ± 3.73.84
30084.3 ± 4.04.74106 ± 6.66.23
3000104 ± 32.88111 ± 65.41

Genipin1081.2 ± 11.013.55106 ± 98.49
3081.0 ± 7.49.14115 ± 21.74
300111 ± 119.91104 ± 98.65
3000114 ± 54.3992.9 ± 5.25.60

Crocetin10103 ± 8.7.7789.1 ± 4.24.71
3095.8 ± 10.010.4494.3 ± 6.87.21
30099.2 ± 13.413.5198.0 ± 13.213.47
300098.5 ± 10.010.1598.3 ± 5.45.49