Research Article

Comparative Pharmacokinetics of Geniposidic Acid, Genipin-1-β-Gentiobioside, Geniposide, Genipin, and Crocetin in Rats after Oral Administration of Crude Gardeniae Fructus and Its Three Processed Products Using LC-MS/MS

Table 4

Stability of the 5 compounds (n = 6).

CompoundsConcentration (ng/mL)Freeze-thaw cyclesAt −80°C for a monthAutosampler for 24 h
RSD (%)Remain (%)RSD (%)Remain (%)RSD (%)Remain (%)

Geniposidic acid1010.3796.37.481071.4294.7
305.7110110.1498.06.0596.4
3006.441075.301063.4096.4
30002.431081.5599.93.9496.7

Genipin-1-β-gentiobioside103.7910413.4495.810.4099.3
301.0310510.5096.31.52100
3007.711014.1995.15.96101
30002.601030.8795.12.7590.7

Geniposide104.1097.510.7599.210.57102
305.1792.89.8598.44.1195.1
3001.8893.12.7994.87.9196.3
30005.9295.02.9792.81.2491.6

Genipin103.81101.3.141083.2495.4
304.4395.312.681034.49104
3002.6895.95.981050.7690.6
30009.221006.991014.1292.6

Crocetin102.021029.7598.46.4397.9
308.0595.310.151016.0099.9
3007.0298.66.671054.4196.3
30006.521061.331035.5598.9