Evidence-Based Complementary and Alternative Medicine / 2020 / Article / Tab 4 / Research Article
Comparative Pharmacokinetics of Geniposidic Acid, Genipin-1-β -Gentiobioside, Geniposide, Genipin, and Crocetin in Rats after Oral Administration of Crude Gardeniae Fructus and Its Three Processed Products Using LC-MS/MS Table 4 Stability of the 5 compounds (n = 6).
Compounds Concentration (ng/mL) Freeze-thaw cycles At −80°C for a month Autosampler for 24 h RSD (%) Remain (%) RSD (%) Remain (%) RSD (%) Remain (%) Geniposidic acid 10 10.37 96.3 7.48 107 1.42 94.7 30 5.71 101 10.14 98.0 6.05 96.4 300 6.44 107 5.30 106 3.40 96.4 3000 2.43 108 1.55 99.9 3.94 96.7 Genipin-1-β -gentiobioside 10 3.79 104 13.44 95.8 10.40 99.3 30 1.03 105 10.50 96.3 1.52 100 300 7.71 101 4.19 95.1 5.96 101 3000 2.60 103 0.87 95.1 2.75 90.7 Geniposide 10 4.10 97.5 10.75 99.2 10.57 102 30 5.17 92.8 9.85 98.4 4.11 95.1 300 1.88 93.1 2.79 94.8 7.91 96.3 3000 5.92 95.0 2.97 92.8 1.24 91.6 Genipin 10 3.81 101. 3.14 108 3.24 95.4 30 4.43 95.3 12.68 103 4.49 104 300 2.68 95.9 5.98 105 0.76 90.6 3000 9.22 100 6.99 101 4.12 92.6 Crocetin 10 2.02 102 9.75 98.4 6.43 97.9 30 8.05 95.3 10.15 101 6.00 99.9 300 7.02 98.6 6.67 105 4.41 96.3 3000 6.52 106 1.33 103 5.55 98.9