Research Article

Comparative Pharmacokinetics of Geniposidic Acid, Genipin-1-β-Gentiobioside, Geniposide, Genipin, and Crocetin in Rats after Oral Administration of Crude Gardeniae Fructus and Its Three Processed Products Using LC-MS/MS

Table 5

The main pharmacokinetics of 5 compounds in rat plasma (n = 6).

CompoundsTreatmentCmax (ng/mL)Tmax (h)T1/2 (h)AUC(0–24 h) (ng/L·h)AUC(0–∞) (ng/L·h)

Geniposidic acidCGF1022.83 ± 450.173.33 ± 1.632.52 ± 0.647696.99 ± 2741.288586.63 ± 3450.88
SGF398.33 ± 107.81.78 ± 0.442.93 ± 3.451730.86 ± 618.741774.38 ± 654.94
GCGF669.63 ± 431.893.33 ± 3.431.72 ± 0.692988.13 ± 2302.063250.09 ± 2342
GIGF272.00 ± 164.042.40 ± 1.261.50 ± 0.421187.21 ± 813.411351.01 ± 827.12

Genipin-1-β-gentiobiosideCGF149.90 ± 132.070.55 ± 0.330.72 ± 0.25141.12 ± 104.11237.29 ± 119.51
SGF79.08 ± 39.470.61 ± 0.310.61 ± 0.18109.26 ± 58.78121.03 ± 54.86
GCGF102.92 ± 58.150.78 ± 0.200.78 ± 0.32206.27 ± 142.55233.30 ± 165.74
GIGF62.94 ± 16.811.05 ± 0.370.91 ± 0.36131.30 ± 36.78151.67 ± 48.73

GeniposideCGF1071.67 ± 598.461.54 ± 1.303.21 ± 2.314000.13 ± 1677.194119.45 ± 1649.61
SGF455.44 ± 160.360.89 ± 0.721.61 ± 0.631141.92 ± 389.071200.78 ± 382.09
GCGF581.00 ± 240.710.86 ± 0.131.44 ± 0.531862.67 ± 1078.691899.73 ± 1092.04
GIGF211.50 ± 109.101.30 ± 0.481.08 ± 0.45733.81 ± 519.14781.95 ± 530.75

GenipinCGF76.44 ± 40.931.11 ± 0.403.42 ± 1.94265.30 ± 103.43356.72 ± 139.94
SGF98.05 ± 41.841.00 ± 0.551.39 ± 0.88233.77 ± 141.78281.41 ± 178.60
GCGF68.52 ± 19.411.10 ± 0.521.39 ± 0.98152.67 ± 113.60329.06 ± 394.68
GIGF

CrocetinCGF165.02 ± 52.867.30 ± 3.9341.65 ± 57.621251.80 ± 354.9810824.60 ± 13505.86
SGF152.51 ± 81.906.61 ± 4.0556.17 ± 42.991258.95 ± 596.557510.78 ± 8494.79
GCGF162.66 ± 76.436.43 ± 5.0212.75 ± 6.641098.06 ± 522.583845.62 ± 5252.68
GIGF91.18 ± 35.651.29 ± 2.3131.84 ± 29.27621.22 ± 389.713610.39 ± 2206.09

CGF as control group, ; , SGF as control group, ; .