Evidence-Based Complementary and Alternative Medicine / 2020 / Article / Tab 5 / Research Article
Comparative Pharmacokinetics of Geniposidic Acid, Genipin-1-β -Gentiobioside, Geniposide, Genipin, and Crocetin in Rats after Oral Administration of Crude Gardeniae Fructus and Its Three Processed Products Using LC-MS/MS Table 5 The main pharmacokinetics of 5 compounds in rat plasma (n = 6).
Compounds Treatment C max (ng/mL)T max (h)T 1/2 (h)AUC(0–24 h) (ng/L·h) AUC(0–∞) (ng/L·h) Geniposidic acid CGF 1022.83 ± 450.17 3.33 ± 1.63 2.52 ± 0.64 7696.99 ± 2741.28 8586.63 ± 3450.88 SGF 398.33 ± 107.8 1.78 ± 0.44 2.93 ± 3.45 1730.86 ± 618.74 1774.38 ± 654.94 GCGF 669.63 ± 431.89 3.33 ± 3.43 1.72 ± 0.69 2988.13 ± 2302.06 3250.09 ± 2342 GIGF 272.00 ± 164.04 2.40 ± 1.26 1.50 ± 0.42 1187.21 ± 813.41 1351.01 ± 827.12 Genipin-1-β -gentiobioside CGF 149.90 ± 132.07 0.55 ± 0.33 0.72 ± 0.25 141.12 ± 104.11 237.29 ± 119.51 SGF 79.08 ± 39.47 0.61 ± 0.31 0.61 ± 0.18 109.26 ± 58.78 121.03 ± 54.86 GCGF 102.92 ± 58.15 0.78 ± 0.20 0.78 ± 0.32 206.27 ± 142.55 233.30 ± 165.74 GIGF 62.94 ± 16.81 1.05 ± 0.37 0.91 ± 0.36 131.30 ± 36.78 151.67 ± 48.73 Geniposide CGF 1071.67 ± 598.46 1.54 ± 1.30 3.21 ± 2.31 4000.13 ± 1677.19 4119.45 ± 1649.61 SGF 455.44 ± 160.36 0.89 ± 0.72 1.61 ± 0.63 1141.92 ± 389.07 1200.78 ± 382.09 GCGF 581.00 ± 240.71 0.86 ± 0.13 1.44 ± 0.53 1862.67 ± 1078.69 1899.73 ± 1092.04 GIGF 211.50 ± 109.10 1.30 ± 0.48 1.08 ± 0.45 733.81 ± 519.14 781.95 ± 530.75 Genipin CGF 76.44 ± 40.93 1.11 ± 0.40 3.42 ± 1.94 265.30 ± 103.43 356.72 ± 139.94 SGF 98.05 ± 41.84 1.00 ± 0.55 1.39 ± 0.88 233.77 ± 141.78 281.41 ± 178.60 GCGF 68.52 ± 19.41 1.10 ± 0.52 1.39 ± 0.98 152.67 ± 113.60 329.06 ± 394.68 GIGF — — — — — Crocetin CGF 165.02 ± 52.86 7.30 ± 3.93 41.65 ± 57.62 1251.80 ± 354.98 10824.60 ± 13505.86 SGF 152.51 ± 81.90 6.61 ± 4.05 56.17 ± 42.99 1258.95 ± 596.55 7510.78 ± 8494.79 GCGF 162.66 ± 76.43 6.43 ± 5.02 12.75 ± 6.64 1098.06 ± 522.58 3845.62 ± 5252.68 GIGF 91.18 ± 35.65 1.29 ± 2.31 31.84 ± 29.27 621.22 ± 389.71 3610.39 ± 2206.09
CGF as control group,
; , SGF as control group,
; .