Evaluation of Methanol-Dichloromethane Extract of Stemonocoleus micranthus Harms (Fabaceae) Stem Bark for Anti-Inflammatory and Immunomodulatory Activities

Table 2

Effect of MDESm on carrageenan-induced rat paw oedema.

Treatment	Dose (mg/kg)	1 h	2 h	3 h	4 h	5 h	AUC (mlh)
		Oedema (ml)
Control (dist. water)	2 ml/kg	0.42 ± 0.10	0.76 ± 0.074	0.82 ± 0.047	1.00 ± 0.063	0.98 ± 0.058	3.490 ± 0.245
Ibuprofen	100	0.16 ± 0.07 (61.9)	0.28 ± 0.09 (63.2)	0.30 ± 0.12 (63.4)	0.36 ± 0.12 (64.0)	0.33 ± 0.11 (66.32)	1.270 ± 0.345
MDESm	100	0.24 ± 0.02 (42.9)	0.52 ± 0.09 (31.6)	0.40 ± 0.14 (51.2)	0.52 ± 0.15 (48.0)	0.42 ± 0.14 (57.1)	1.890 ± 0.392
MDESm	200	0.30 ± 0.09 (28.6)	0.66 ± 0.11 (13.2)	0.78 ± 0.14 (4.9)	0.70 ± 0.13 (30.0)	0.76 ± 0.12 (22.5)	2.820 ± 0.396
MDESm	400	0.34 ± 0.07 (19.1)	0.75 ± 0.15 (1.3)	0.94 ± 0.06 (−14.6)	0.98 ± 0.04 (2.0)	0.92 ± 0.05 (6.1)	3.480 ± 0.289

Mean ± SEM, n = 5; compared to control (one-way ANOVA; Dunnett’s post hoc test); values in parentheses are percentage oedema reduction compared to control. MDESm = methanol-dichloromethane extract of Stemonocoleus micranthus; AUC = area under the curve.