Evaluation of Methanol-Dichloromethane Extract of Stemonocoleus micranthus Harms (Fabaceae) Stem Bark for Anti-Inflammatory and Immunomodulatory Activities
Table 5
Effect of MDESm on neutrophil index and neutrophil adhesion in rats.
Treatment
Dose (mg/kg)
TLC (cells/mm3) (x)
% neutrophil (y)
Neutrophil adhesion (%)
Neutrophil index (xy)
UnB
FTB
UnB
FTB
UnB
FTB
Control (dist. water)
1 (ml/kg)
11128 ± 1593
6180 ± 1194
24.2 ± 3.32
15.0 ± 2.19
272000 ± 51722
96560 ± 25850
64.50
Levamisole
50
8040 ± 1073
6500 ± 1121
19.6 ± 1.91
12.4 ± 1.12
156280 ± 20293
83160 ± 20426
46.78
MDESm
100
13900 ± 1100
11475 ± 891
28.8 ± 1.49
20.5 ± 70
401000 ± 43287
236050 ± 27009
41.13
MDESm
200
15440 ± 3068
11140 ± 1573
24.0 ± 3.98
18.2 ± 3.69
346400 ± 54386
190380 ± 34520
45.04
MDESm
400
9560 ± 927
7700 ± 559
23.0 ± 3.82
15.0 ± 3.17
210880 ± 17759
114280 ± 25910
45.80
Mean ± SEM, n = 5; compared to control (one-way ANOVA; Dunnett’s post hoc test). UnB: untreated blood; FTB: nylon fibre-treated blood; MDESm: methanol-dichloromethane extract of Stemonocoleus micranthus.
