The Protective Effect of Qishen Granule on Heart Failure after Myocardial Infarction through Regulation of Calcium Homeostasis

<div>Effects of QSG on expressions of CaV1.2 and SERCA2a in HF rats after AMI. (a) Immunohistochemistry images of CaV1.2 and quantitative results in the heart tissues of rats in different groups. (b) WB bands of CaV1.2 and its quantitative results in the heart tissues of rats. (c) WB bands of SERCA2a and its quantitative results in the heart tissues of rats. IHC and WB results showed that the expression of CaV1.2 in the model group was upregulated compared with the sham group. QSG-L and QSG-H could decrease levels of CaV1.2 compared with the model group. Western blot showed that the expression of SERCA2a in the model group was downregulated compared with the sham group. QSG-L and QSG-H could increase protein levels of SERCA2a significantly compared with the model group. <svg height="12.1645pt" id="M33" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -11.5275 64.9458 12.1645" width="64.9458pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,4.432,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,8.863,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 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Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: The Protective Effect of Qishen Granule on Heart Failure after Myocardial Infarction through Regulation of Calcium Homeostasis 