Evidence-Based Complementary and Alternative Medicine

Research Article

Biocurcumin as Radiosensitiser for Cervical Cancer Study (BRACES): A Double-Blind Randomised Placebo-Controlled Trial

Table 1

Analysis of BCM-95’s components.
DescriptionSpecificationTest methodResults
IdentificationPassTLCComplies
ColorOrange redVisualComplies
AppearancePowderVisualComplies
FlavorCharacteristicOrganolepticComplies
OdorCharacteristicOrganolepticComplies
Analytical assay   
Herb exact ratio25 : 1In-house specificationComplies
Solubility (in acetone) (in waterSoluble InsolubleIP IPComplies Complies
MoistureNMT 2%USP <921>0.2%
Extraction solvent100% ethyl acetateIn-house specificationComplies
Particle size100% through 30 meshUSP <786>Complies
AllergensNone detectedElisaComplies
Tap density (g/ml)NLT 0.60USP <616>0.82
Bulk density (g/ml)NLT 0.39USP <616>0.61
Pesticide residueComplies with USPUSP <561>Complies
ExcipientsNoneIn-house specificationComplies
CarriersNoneIn-house specificationComplies
Residual solvents   
BenzeneAs per USPUSP <467>Complies
Carbon tetrachlorideAs per USPUSP <467>Complies
1,2-DichloroethaneAs per USPUSP <467>Complies
1,1-DichloroethaneAs per USPUSP <467>Complies
1,1,1-TrichloroethaneAs per USPUSP <467>Complies
Ethyl acetateAs per USPUSP <467>Complies
EthanolAs per USPUSP <467>Complies
AcetoneAs per USPUSP <467>Complies
Trace metals   
Total heavy metalsNMT 10 ppmICP-MS0.3911 ppm
ArsenicNMT 1 ppmICP-MS0.0183 ppm
LeadNMT 0.5 ppmICP-MS0.3728 ppm
MercuryNMT 1 ppmICP-MSBDL
(BDL: As, 0.02 ppb; Pb, 0.015 ppb; Hg, 0.02 ppb)   
Microbiological assay   
Total plate countNMT 1,000 cfu/gAOAC, BAM20 cfu/g
Yeast and moldNMT 100 cfu/gAOAC, BAM10 cfu/g
SalmonellaAbsent/25 gAOAC, BAMComplies
E. coliAbsent/10 gAOAC, BAMComplies
Staphylococcus aureusAbsent/10 gAOAC, BAMComplies
Pseudomonas aeruginosaAbsent/10 gAOAC, BAMComplies
AflatoxinAbsentAOAC, BAMComplies
ColiformsAbsent/10 gAOAC, BAMComplies
(Microbial assay detection limit: 10 cfu/g)   
Assay for actives   
Volatile compounds of turmericPresentUV-VisComplies
Total curcuminoids complexNLT 95%HPLC98.39%
Consisting of curcumin, desmethoxy curcumin, bis-desmethoxy curcumin, and volatile oils of turmeric rhizome   
Total curcuminoidsNLT 86%HPLC91.39%
CurcuminNLT 65%HPLC71.96%
BCM-95 and Biocurcumin are registered trademarks of Dolcas Biotech LLC, 9 Lenel Road, Landings, http://www.dolcas-biotech.com