The Therapeutic Effect of Shark Liver Oil in a Rat Model of Acetic Acid-Induced Ulcerative Colitis

Figure 3

Histopathological features of colonic tissue biopsy specimens of ulcerative colitis-induced rats. (a) Normal saline: ulceration with mucosal regeneration, irregularity in crypt structure, goblet cell depletion, and inflammation of the mucosa. (b) Gel base: ulceration with mucosal regeneration and inflammation of the mucosa. (c) Asacol: near-complete regeneration of mucosa. (d) Mesalazine: ulceration with mucosal regeneration and inflammation of mucosa. (e) SLO 5%, rectal: ulceration with mucosal regeneration and inflammation of mucosa. (f) SLO 10%, rectal: near-complete regeneration of mucosa. (g) SLO 200 mg, oral: ulceration with adjacent mucosal regeneration. (h) SLO 400 mg, oral: focal surface ulceration with mucosal regeneration. H&E, ×100. N, normal tissue; R, regeneration; U, ulcer.

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