Green Tea Polyphenols Protect against Acetaminophen-Induced Liver Injury by Regulating the Drug Metabolizing Enzymes and Transporters

<div>Effects of GTP on drug transporters in mice. Different doses (37.5 mg/kg, 75 mg/kg, or 150 mg/kg) of GTP were orally given to mice 4 h after a single dose of APAP (400 mg/kg) administration with an interval of 8 h. Mice were sacrificed at 4, 12, 20, or 48 h after the first dose of GTP. Liver samples were harvested and processed as indicated in Materials and Methods. P-gp (a) or Mrp2 (b) protein levels were analyzed. Data are expressed as fold change over the control group. 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Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: Green Tea Polyphenols Protect against Acetaminophen-Induced Liver Injury by Regulating the Drug Metabolizing Enzymes and Transporters 