Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyus Hocsht: Ex Del. (Euphorbiaceae) in Rodents

Table 3

Effects of the fractions of the C. macrostachyus root extract on the acidified ethanol induced ulcer model in mice.

Groups	Dose	Average ulcer no. (UN)	Ulcer index (UI)	% of ulcer inhibition
I	NC	4.33	20.58 ± 1.27	--—
II	CF100	1.5	9.67 ± 3.07^a1	53.0
III	CF200	0.83	6.42 ± 2.89^a2	68.8
IV	CF400	0.67	4.50 ± 2.89^a3	78.1
V	EF100	3.33	16.75 ± 0.80^d1e3	18.6
VI	EF200	1.5	11.00 ± 2.29^a1	46.6
VII	EF400	0.67	7.66 ± 2.42^a2b1	62.8
VIII	AF100	3.83	18.17 ± .65^e3	11.7
IX	AF200	3.67	18.25 ± 0.48^e3	11.32
X	AF400	3.17	16.17 ± 1.48^e3	21.4
XI	SUC100	0.33	3.83 ± 2.42^a3b3c3d3	81.4

Values are expressed as Mean ± SEM, n = 6, , , , ^acompared to NC, ^bcompared to 100 mg/kg, ^ccompared to 200 mg/kg, ^dcompared to 400 mg/kg, and ^e compared to SUC100. Statistically analyzed by one-way ANOVA followed by the Tukey test.