Neuroprotective Effects of Lindleyin on Hydrogen Peroxide-Induced Cell Injury and MPTP-Induced Parkinson’s Disease in C57BL/6 Mice

Figure 5

Lin alleviated functional disturbance in the MPTP-induced PD model. (a) MPTP-induced motor disability was evaluated with the rotarod test. All mice were pretrained for 3 days on the rotarod. The MPTP-treated group had significantly poorer rotarod performance than treatment normal controls, but morin pretreatment (5 or 20 mg/kg) before MPTP improved rotarod performance vs. the MPTP-treated group at 4, 24, 48, and 72 hours after final MPTP treatment. (b) Lin attenuated MPTP-induced dopaminergic neuronal loss in Str and SNpc. TH immunostaining analyses were performed on SNpc and Str.

(a)

(b)