Research Article

Glycyrrhetinic Acid-Induced MiR-663a Alleviates Hepatic Stellate Cell Activation by Attenuating the TGF-β/Smad Signaling Pathway

Figure 4

GA inhibited HSC growth and activation. (a) LX2 and L02 cell proliferation were determined by MTS assays with or without GA at the indicated concentrations (5–60 μM) for 48 h , compared with the untreated control cells. (b) and (c) Effect of GA on HSC activation. The protein expression of COL1A2 and α-SMA was significantly decreased at 48 h () after GA treatment in LX2 cells. Each value is the mean ± SD of three experiments. , compared with the untreated control cells (NC) and , compared with the TGF-β1 group.
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