The Combinatorial Effect of Cisplatin and Moxibustion on Tumor Growth Inhibition with Special Reference to Modulation of the Immune Microenvironment in Lewis Lung Cancer Mice

Figure 1

The effect of combinatorial cisplatin and moxibustion treatment on tumor growth in LLC-bearing mice. (a) Flowchart of experimental interventions. ^●Cisplatin, ^▪moxibustion, and ^★tumor volume test. LLC cells were transplanted into mice on day 0. The mice in the cisplatin (TC) and the combinatorial therapy groups (TCM) were treated with cisplatin on days 7, 10, 14, and 17. Mice in the moxibustion (TM) and the combination groups (TCM) were treated with moxibustion on days 7‐11 (once a day). The tumor volume was measured on days 7, 10, 14, 17, and 21, and mice were sacrificed on day 21 for sample collection. (b) Illustration of moxibustion intervention. (c) Tumor growth curve analysis of the LLC-bearing mice in each group at the corresponding time points (days 7, 10, 14, 17, and 21; n = 7). (d) Images of the dissected tumors from each group (n = 7). (e) The area of tumor tissues in each group (n = 7). (f) Tumor weight after removal from mice at day 21 (n = 7). (g) Effects of cisplatin and moxibustion on the net body weight of LLC-bearing mice. Data in (c), (e), (f), and (g) are mean ± SEM, , , and vs. T; and vs. TC; and vs. TM.

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