Gandouling Tablets Inhibit Excessive Mitophagy in Toxic Milk (TX) Model Mouse of Wilson Disease via Pink1/Parkin Pathway

Figure 2

Mitochondrial ultrastructural changes in the hippocampal tissue of mouse model of Wilson disease (2 μm, 500 nm). (a) The control group with normal mitochondrial ultrastructures. (e) Enlargement of the boxed area in (a) and abundant normal mitochondrial ultrastructure were observed. (b) Abundant mitochondria appeared to be dissolved, swollen, show vacuolization, and obvious mitochondrial autophagosomes were observed in the Wilson group. (f) Enlargement of the boxed area in (b). (c) Few mitochondrial vacuolizations were observed in the DPA group. (g) Enlargement of the boxed area in (c). (d) Lysosomes were observed in neurons and no obvious abnormalities were found in the GDL group, and few mitochondria appeared to have vacuolization. (h) Enlargement of the boxed area in (d) and many lysosomes were observed obviously.

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