Metabolomics of the Protective Effect of Ampelopsis grossedentata and Its Major Active Compound Dihydromyricetin on the Liver of High-Fat Diet Hamster

Table 2

Trends of metabolites concentration in liver of hamsters.

No.	Metabolites	HFD/ND	Trend	AG/HFD	Trend	DMY/HFD	Trend
1.	1,3-Dihydroxyacetone	1.87	↑	1.07	—	0.88	—
2.	2′-Deoxyadenosine	N	N	0.44	↓	0.42	—
3.	3-Hydroxybutyrate	1.72	↑	0.89	—	0.80	—
4.	3-Methyl-2-oxovalerate	2.83	↑	1.72	↑	1.15	—
5.	4-Aminobutyrate	0.34	↓	1.53	↑	1.93	↑
6.	Acetate	0.39	↓	1.44	↑	1.25	↑
7.	Acetoacetate	0.16	↓	0.10	↓	0.10	—
8.	Acetone	0.33	↓	19.63	↑	16.18	↑
9.	Adenine	2.75	↑	53.55	↑	38.93	↑
10.	Alanine	0.74	↓	0.46	↓	0.40	↓
11.	Allantoin	1.62	↑	0.14	↓	0.13	—
12.	Ascorbate	0.73	↓	0.15	↓	0.07	—
13.	Asparagine	1.95	↑	1.78	↑	1.28	↑
14.	Aspartate	1.17	—	2.10	↑	1.43	↑
15.	Betaine	0.73	↓	0.84	—	1.34	↑
16.	Choline	1.82	↑	1.56	↑	1.19	↑
17.	Creatine	2.33	↑	0.87	—	0.81	—
18.	Cytidine	N	N	0.19	↓	0.14	↓
19.	Dimethylamine	0.58	—	1.95	↑	1.48	↑
20.	Ethanol	1.10	—	38.32	↑	24.37	↑
21.	Ethanolamine	0.61	↓	0.19	↓	0.15	—
22.	Formate	0.20	↓	6.27	↑	10.62	↑
23.	Fumarate	0.15	↓	216.28	↑	166.51	↑
24.	Glucose	0.14	↓	0.74	—	0.56	—
25.	Glutamate	1.33	↑	1.15	—	0.94	—
26.	Glutamine	1.58	↑	1.45	↑	1.03	—
27.	Glycine	1.34	↑	0.68	↓	0.46	↓
28.	Histidine	0.96	—	0.17	↓	0.17	↓
29.	Hypoxanthine	0.40	↓	0.51	↓	0.73	↓
30.	Inosine	N	N	62.53	↑	38.79	↑
31.	Isoleucine	2.13	↑	0.01	↓	0.01	↓
32.	Lactate	0.71	↓	0.98	—	0.87	—
33.	Leucine	2.29	↑	2.00	↑	1.34	↑
34.	Lysine	1.37	↑	2.14	↑	1.23	↑
35.	Malate	0.22	↓	0.12	↓	0.85	—
36.	Maltose	0.00	↓	0.24	↓	0.25	↓
37.	Mannose	0.39	↓	0.17	↓	0.34	↓
38.	Methanol	1.32	↑	25.28	↑	18.04	↑
39.	Methionine	2.02	↑	0.01	↓	0.01	↓
40.	N,N-Dimethylglycine	0.60	↓	17.43	↑	16.56	↑
41.	Niacinamide	0.42	↓	1.61	↑	1.61	↑
42.	O-Phosphocholine	0.68	↓	8.68	—	5.31	↑
43.	Ornithine	1.00	—	0.06	↓	0.05	↓
44.	Pantothenate	0.42	↓	46.76	↑	30.36	↑
45.	Phenylalanine	2.23	↑	1.78	↑	1.21	↑
46.	Proline	1.07	—	0.38	↓	0.27	↓
47.	Pyroglutamate	1.61	↑	1.76	↑	1.93	↑
48.	Ribose	0.41	↓	0.01	↓	0.02	↓
49.	Sarcosine	0.58	↓	355.17	↑	251.75	↑
50.	Serine	1.07	—	0.31	↓	0.24	↓
51.	Succinate	10.53	↑	2.80	↑	2.84	↑
52.	Taurine	1.92	↑	2.56	↑	1.72	↑
53.	Threonine	1.56	↑	0.04	↓	0.03	↓
54.	Thymidine	N	N	4.07	↑	3.70	↑
55.	Thymine	13.60	↑	0.03	↓	0.02	↓
56.	Trimethylamine	0.44	↓	788.09	↑	498.96	↑
57.	Tryptophan	2.37	↑	8.43	↑	5.74	↑
58.	Tyrosine	3.17	↑	0.29	↓	0.25	↓
59.	Uracil	0.69	↓	4.24	↑	4.22	↑
60.	Urea	0.38	↓	0.07	↓	0.08	↓
61.	Uridine	0.16	↓	88.88	↑	60.22	↑
62.	Valine	1.87	↑	0.00	↓	0.01	↓
63.	Xanthosine	0.40	↓	16.82	↑	14.64	↑
64.	Myo-inositol	N	N	2.03	↑	1.40	↑
65.	sn-Glycero-3-phosphocholine	2.01	↑	3.06	↑	2.09	↑
66.	β-Alanine	1.32	↑	1.35	↑	0.86	—

Note: compared with HFD, ; compared with HFD, ; N means that it cannot be calculated.