Kai-Xin-San, a Chinese Herbal Decoction, Accelerates the Degradation of β-Amyloid by Enhancing the Expression of Neprilysin in Rats

Figure 2

KXS prevented the cognitive deficit induced by Aβ42 injection. (a) In the navigation test, the average escape latency of each group changed gradually and became shorter following training during the 5 days. From the 3rd to 5th day, the average escape latency of the Aβ group was significantly longer than that in the sham group and Aβ + KXS group (, ; n = 10). (b) In the spatial probe test, the average times of the animals swimming across the platform area of the Aβ group were reduced significantly compared to that of the sham group. After the oral administration of KXS, the average times were significantly increased (, ; n = 10).

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