|
| Dose | Control | 1% GF | 2% GF |
| Rat ID no. | 51 | 52 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 72 | 73 | 74 | 75 | 76 | 77 | 78 | 79 | 82 | 85 | 86 | 88 | 90 |
| Tissue observation |
|
| Ileum (H&E and Masson trichrome staining) | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Colon | | | | | | | | | | | | | | | | | | | | | | | |
| Deposit, eosinophilic, lamina propria | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — |
| Fibrosis, mesocolon, perivenus region | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — |
| Fibrosis, lamina propria (Masson trichrome staining) | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — |
| Mesentery (H&E and Masson trichrome staining) | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Spleen | | | | | | | | | | | | | | | | | | | | | | | |
| Decreased pigmentation (hemosiderin) | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 2 | — | 1 | — |
| Increased extramedullary hematopoiesis | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — | — | — |
| Decreased lymphoid cell PALS | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — |
| Liver | | | | | | | | | | | | | | | | | | | | | | | |
| Cell infiltration (lymphoid cell), periportal | — | — | 1 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 2 | 1 | 1 | 1 | 1 |
| Pigmentation (brown, granular), hepatocyte | — | — | — | — | — | — | — | — | — | — | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Atrophy, hepatocyte, centrilobular | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | 1 | 2 | 1 | 1 |
| Decreased vacuole, periportal hepatocyte | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | 2 | — | — |
| Vacuolation, hepatocellurar, focal | — | — | — | 1 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Vacuolation, hepatocellurar, periportal | — | — | — | — | 1 | — | — | — | 1 | — | 1 | — | — | 1 | 1 | — | — | — | 1 | 1 | — | — | — |
| Regeneration, hepatocellular, focal | — | — | — | — | — | — | — | — | — | — | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Adrenal | | | | | | | | | | | | | | | | | | | | | | | |
| Congestion/hemorrhage, cortex | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — |
| Kidney | | | | | | | | | | | | | | | | | | | | | | | |
| Mineralization, corticomedullary junction | 2 | 1 | — | — | 1 | — | — | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 2 | 2 |
| Pigmentation (brown, granular), proximal tubule | — | — | — | — | — | — | — | — | — | — | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 2 |
| Cast, focal | — | P | — | — | — | — | — | — | — | — | P | — | — | P | P | — | — | P | — | P | 2 | — | — |
| Fibrosis, cortex, focal | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — | — |
| Chronic progressive nephritis | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | 1 | — | — |
|
