ErMiao San Inhibits Angiogenesis in Rheumatoid Arthritis by Suppressing JAK/STAT Signaling Pathways

<div>Therapeutic effects of EMS on collagen-induced arthritis (CIA) mice. CIA mice were orally administered EMS (5 g/kg/d), or vehicle for 20 days from the day of second immunization. (a) Macroscopic evidence of arthritis such as erythema or swelling was observed in mouse paws from each group. (b) Representative images of hematoxylin-eosin staining of ankle joint sections from each group. (c) Arthritis score was scored using a scale of 0-4 for each paw, with a maximum possible score of 16. (d) Arthritis incidence values are the number of positives/total number in each group. (e) The histological scores were evaluated and analyzed. 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240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,55.606,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.846,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>,</span> compared with the CIA group.</div>

Evidence-Based Complementary and Alternative Medicine

fig1

Figure 1

Figure 1: ErMiao San Inhibits Angiogenesis in Rheumatoid Arthritis by Suppressing JAK/STAT Signaling Pathways 