Effects and Mechanisms of Electroacupuncture on Chronic Inflammatory Pain and Depression Comorbidity in Mice

Figure 1

EA significantly attenuated mechanical, thermal hyperalgesia, and depression induced by CFA. (a) Changes in the withdraw threshold of mice in the von Frey test. (b) Changes in the withdraw latency of mice in the radial heat test. Figures 1(c) and 1(d) present the day 28 OFT results. After accepting EA, the time mice stayed in the center area longer. (c) The distance mice stayed in the central area. (d) The percentage of time mice spent in the center area. Day 28 FST results are presented in Figures 1(e) and 1(f). EA reduced the immobility of mice. (e) Duration of immobility spent in the FST. (f) Frequency of immobility counted in the FST. for CIP versus control. for EA versus CIP.

(a)

(b)

(c)

(d)

(e)

(f)