An In Vitro Verification of the Effects of Paeoniflorin on Lipopolysaccharide-Exposed Microglia

Figure 1

Changes in cytokines induced by the administration of PF to LPS-exposed microglia. Exposure to LPS significantly enhanced proinflammatory TNF-α (a), IL-1β (b), IL-6 (c), and IFNγ (d) levels, whereas the administration of PF significantly reversed these enhancements. Exposure to LPS significantly decreased anti-inflammatory IL-4 (e) and IL-10 (f) levels, whereas the administration of PF reversed these reductions. One dose of 200 μm caused significant changes (). Data are shown as mean values ± SD, ## means LPS vs. control; means , PF vs. LPS.

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