Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines

<div>Chrysophanol caused cell death via apoptosis. Chrysophanol induced ROS production, increasing the subG1 population and phenomena of apoptosis. NAC reversed chrysophanol-induced cell cytotoxicity. On the other hand, chrysophanol caused G1 phase arrest via regulations of p53, p21, and cell cycle G1 checkpoint-associated molecules.</div>

Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines 