Network Pharmacology-Based Strategy for Predicting Therapy Targets of Traditional Chinese Medicine Xihuang Pill on Liver Cancer

Table 1

The top 20 pathways enriched by the overlapping genes between Xihuang pill targets and liver cancer molecular targets.

ID	Pathway description	Count	FDR
1100	Metabolic pathways	35	2.81E − 16
5200	Pathways in cancer	24	4.18E − 19
5205	Proteoglycans in cancer	18	4.38E − 15
4151	PI3K-Akt-signaling pathway	15	4.16E − 09
4915	Estrogen-signaling pathway	13	9.30E − 14
4015	Rap1-signaling pathway	13	1.04E − 09
4066	HIF-1-signaling pathway	12	9.29E − 12
4510	Focal adhesion	11	1.12E − 07
4014	Ras-signaling pathway	11	2.20E − 07
1230	Biosynthesis of amino acids	10	9.36E − 11
5218	Melanoma	10	9.36E − 11
5215	Prostate cancer	10	5.39E − 10
4068	FoxO-signaling pathway	10	1.29E − 08
5206	MicroRNAs in cancer	10	5.79E − 08
5219	Bladder cancer	8	4.16E − 10
4370	VEGF-signaling pathway	8	1.34E − 08
5212	Pancreatic cancer	8	1.64E − 08
4914	Progesterone-mediated oocyte maturation	8	1.12E − 07
4912	GnRH-signaling pathway	8	2.20E − 07
5210	Colorectal cancer	7	2.20E − 07

Count, the number of genes enriched in certain pathways; FDR, false discovery rate.