Herbal Medication, Macmoondong Decoction, Attenuates LPS-Induced COPD in Small Airways via TGF-β, CCL-2, and CXCL1

Figure 4

Macmoondong decoction inhibited the typical changes observed in COPD. (a) In the H&E-stained sections of the lung, macmoondong decoction suppressed the morphological changes related to COPD, such as mucous hypersecretion and inflammatory cell infiltration near the small airways. (b) In Masson’s trichrome-stained sections of the lung, macmoondong decoction dose-dependently prevented fibrogenicity. N = 6. Scale bar =100 μm. (A) control; (B) 0.8 mg/kg COPD induction group; (C) 1 mg/kg Spiriva treatment for 5 days after a single LPS instillation; (D) 150 mg/kg macmoondong decoction treatment for 5 days after a single LPS instillation; (E) 1500 mg/kg macmoondong decoction treatment for 5 days after a single LPS instillation.

(a)

(b)