Herbal Medication, Macmoondong Decoction, Attenuates LPS-Induced COPD in Small Airways via TGF-β, CCL-2, and CXCL1

Figure 5

Macmoondong decoction dose-dependently suppressed the DNA expression of TGF-β, CCL-2, CXCL1, and CXCL11. (a) The DNA expression of TGF-β in the macmoondong decoction-treated groups was lower than that in the Spiriva treatment group; in addition, a dose-dependent suppression was observed. (b) The change in DNA expression of CCL-2 was similar to the pattern in TGF-β. (c) Macmoondong decoction effectively downregulated the DNA expression of CXCL1; the pattern of changes was very similar to that of TGF-β. (d) Compared with the changes in other genes, such as TGF-β, CCL-2, and CXCL1, small changes were observed, but macmoondong decoction effectively suppressed the DNA expression of CXCL11. Each bar represents the mean ± SD (N = 8). vs. control group; vs. control group; vs. COPD induction group; vs. COPD induction group; vs. Spiriva treatment group; vs. Spiriva treatment group.

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