Herbal Medication, Macmoondong Decoction, Attenuates LPS-Induced COPD in Small Airways via TGF-β, CCL-2, and CXCL1

Figure 6

Macmoondong decoction dose-dependently suppressed the expression of TGF-β, CCL-2, CXCL1, and CXCL11. (a) In the 1500 mg/kg macmoondong decoction treatment group, the expression of TGF-β was lower than that in the Spiriva treatment group, and dose-dependent inhibition was observed. (b) Macmoondong decoction significantly inhibited the expression of CCL-2 in a dose-dependent manner, and in the 1500 mg/kg macmoondong decoction treatment group, the suppression of CCL-2 was more effective than that in Spiriva treatment. (c) Macmoondong decoction dose-dependently downregulated the expression of CXCL1. (d) Similar to the changes in CXCL1, macmoondong decoction exerted dose-dependent suppression. (e) The positively stained cell counts for TGF-β, CCL-2, CXCL1, and CXCL11. Each bar represents the mean ± SD (N = 8). vs. control group; vs. control group; vs. COPD induction group; vs. COPD induction group; vs. Spiriva treatment group; vs. Spiriva treatment group.

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