Evaluation of Antidiabetic Activity of Ajuga integrifolia (Lamiaceae) Root Extract and Solvent Fractions in Mice

Table 4

The activity of repeated daily doses of crude extract of AIRE on hyperglycemia in STZ-induced diabetic mice.

Blood glucose level (mg/dl)
Group	FBGL at baseline	FBGL after 7 days	FBGL after 14 days	R (%) at 7 days	R (%) at 14 days
DW10 ml/kg	391.6 ± 2.249	393.8 ± 1.967	397.6 ± 4.226	−0.56	−1.50
AIRE100 mg/kg	416 ± 27.817	349.4 ± 17.657^Axβznx	338.9 ± 19.530^Axβznx	16.10	18.50
AIRE200 mg/kg	377.4 ± 21.970	296.6 ± 11.369^Axβznx	284.4 ± 4.760^Ayβznx	21.40	24.60
AIRE400 mg/kg	393 ± 11.176	288.5 ± 9.963^Axβzny	279.8 ± 10.856^Axβzny	26.50	28.80
GLC5 mg/kg	376.4 ± 8.698	147.2 ± 3.056^AyByCxDxβyny	129.4 ± 3.429^AzByCxDxβzny	60.80	65.60
Normal control	77.6 ± 7.987	77.4 ± 2.966	77.2 ± 1.815	0.25	0.51

N = 6 for each treatment; each value is presented in mean ± SEM. ^ACompared to diabetic control; ^βcompared to the baseline blood glucose level; ^Bcompared to 100 mg/kg AIRE; ^Ccompared to 200 mg/kg AIRE; ^Dcompared to 400 mg/kg AIRE; ⁿcompared to normal control. . DW, distilled water; GLC, glibenclamide; AIRE, Ajuga integrifolia root extract; R, reduction.