Evaluation of Antidiabetic Activity of Ajuga integrifolia (Lamiaceae) Root Extract and Solvent Fractions in Mice

Table 6

The activity of single doses of three fractions of AIRE on hyperglycemia in STZ-induced diabetic mice.

Blood glucose level (mg/dl)
Group	0 hr	2 hr	4 hr	6 hr	8 hr
DW10 ml/kg	391.6 ± 5.03	393.2 ± 3.023	391.6 ± 4.261	388.6 ± 3.487	391.8 ± 2.223
AQA100 mg/kg	415.8 ± 62.311	396 ± 34.095	401.6 ± 10.870	394 ± 5.621	388.4 ± 27.817
AQA200 mg/kg	375.4 ± 52.600	336.2 ± 22.030	316.8 ± 21.224	323.4 ± 19.065	312.7 ± 23.376^AxCxHxβx
AQA400 mg/kg	393 ± 24.900	354.2 ± 18.940	359.4 ± 10.539	334.6 ± 7.004	309.8 ± 5.643^AxCxHxβx
HX100 mg/kg	376.4 ± 8.698	384.8 ± 5.526	372.4 ± 14.590	370 ± 9.560	377.8 ± 11.508
HX200 mg/kg	387 ± 12.892	373.2 ± 16.451	399.4 ± 11.830	413 ± 16.257	378.6 ± 10.722
HX400 mg/kg	395.6 ± 15.045	421.2 ± 16.488	418.6 ± 11.927	394.2 ± 5.544	430.4 ± 24.330
CHL100 mg/kg	385.8 ± 8.470	388.2 ± 3.917	399 ± 9.365	390.2 ± 15.160	397.2 ± 9.754
CHL200 mg/kg	394.2 ± 8.381	405.2 ± 17.080	407.8 ± 24.800	418.6 ± 13.851	401.2 ± 11.770
CHL400 mg/kg	386.8 ± 7.179	380.2 ± 5.324	306 ± 12.779	406.4 ± 8.334	387.8 ± 4.375
GBC5 mg/kg	376.4 ± 19.450	292.6 ± 8.004^Axβx	240.9 ± 8.213^Axβx	199.2 ± 8.399^Ayβy	134.6 ± 3.842^Azβz

N = 6 for each treatment group; each value is presented in mean ± SEM. ^ACompared to negative control; ^βcompared to baseline; ^Bcompared to 100 mg/kg; ^Ccompared to chloroform; ^Hcompared to hexane. . AQA, aqueous; HX, hexane; CH, chloroform; GLC, glibenclamide.