Protective Effect of Shenqi Maixintong Capsule against ox-LDL-Induced Injury in RAW264.7 Macrophages

Figure 6

Western blot analysis of the expression of ABCA1, ABCG1, LXRα, PPARα, PPARγ, and PCSK9 in RAW264.7 cells. GAPDH was served as an internal control of the protein level. Determined expression of the protein was subsequently quantified by densitometric analysis with that of control being 1.00-fold. The expression of ABCA1, ABCG1, LXRα, PPARα, and PPARγ was decreased, induced by ox-LDL, but the expression of PCSK9 was increased, induced by ox-LDL. After treatment with SMC, ABCA1, ABCG1, LXRα, PPARα, and PPARγ expressions were upregulated and the expression of PCSK9 was downregulated. Results are representative of at least three independent experiments.

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