Preventive Effects of Chrysanthemum coronarium L. Extract on Bone Metabolism In Vitro and In Vivo

Figure 6

The effect of Chrysanthemum coronarium on OVX-induced bone loss in mice. (a) Bone mass density (BMD) of the total femur was measured by dual-energy X-ray absorptiometry. (b) Representative two-dimensional (upper and middle sections) and three-dimensional (lower section) images of the trabecular bone in femurs were analyzed. The yellow box indicates the region of interest. (c) Bone volume to tissue volume (BV/TV) and bone parameters of the femur (trabecular thickness (Tb. Th), trabecular number (Tb. N), and trabecular separation (Tb. Sp)). Data are represented as means ± SEM. SH (sham), sham mice; OVX (ovariectomy), OVX mice; O + Es (estrogen), OVX + Es treatment mice; O + CC (Chrysanthemum coronarium), and OVX + CC treatment mice. Data are represented as means ± SEM, n = 8. , , and compared with SH groups, and compared with OVX groups. CC inhibits serum biochemical markers in OVX-induced bone loss in mice.

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