Effect of Ephedra Herb on Erlotinib Resistance in c-Met-Overexpressing Non-Small-Cell Lung Cancer Cell Line, H1993, through Promotion of Endocytosis and Degradation of c-Met

Figure 1

The combined effect of EHE and erlotinib on growth of H1993 xenograft tumor in vivo. Mice were inoculated subcutaneously with H1993 cells. After 7 days, an oral drug administration protocol was initiated with vehicle, 100 mg/kg/day of erlotinib, 350 mg/kg/day of EHE, and a combination of 100 mg/kg/day of erlotinib and 350 mg/kg/day of EHE. The tumor size (a) and weight of mouse were measured twice a week (b). Each error bar represents the average (n = 6) ± S.D. Data were analyzed by 2-way ANOVA (A : DF = 5, F(5, 120) = 34.17, and ; B : D F = 5, F(5, 126) = 4.21, and ). Significant differences were determined by Dunnett’s test; , , and vs. the vehicle group.

(a)

(b)