Effect of Ephedra Herb on Erlotinib Resistance in c-Met-Overexpressing Non-Small-Cell Lung Cancer Cell Line, H1993, through Promotion of Endocytosis and Degradation of c-Met

<div>The effect of EFE and fractions on overexpression of c-Met and EGFR in H1993 cells. H1993 cells were incubated for 4 h at 37°C in 4 ml RPMI-1640 or 4 ml RPMI-1640 containing 100 <i>µ</i>g/ml EFE, 25 <i>µ</i>g/ml Water Fr, 25 <i>µ</i>g/ml 20% MeOH Fr, 25 <i>µ</i>g/ml 40% MeOH Fr, or 25 <i>µ</i>g/ml MeOH Fr. The expression levels of c-Met, pMet, EGFR, pEGFR, and GAPDH were analyzed by western blotting.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 9

Figure 9: Effect of Ephedra Herb on Erlotinib Resistance in c-Met-Overexpressing Non-Small-Cell Lung Cancer Cell Line, H1993, through Promotion of Endocytosis and Degradation of c-Met 

Figure 9 | Effect of Ephedra Herb on Erlotinib Resistance in c-Met-Overexpressing Non-Small-Cell Lung Cancer Cell Line, H1993, through Promotion of Endocytosis and Degradation of c-Met 