Research Article

An Analysis of the Anti-Neuropathic Effects of Qi She Pill Based on Network Pharmacology

Table 3

The gene, target name, and Uniprot ID in the PPI network in the treatment of NP by QSP.

NumberGeneTarget nameUniprot ID

1ABCB1Multidrug resistance protein 1P08183
2ADORA1Adenosine receptor A1P30542
3ADORA2AAdenosine receptor A2aP29274
4ADRA1AAlpha-1A adrenergic receptorP35348
5ADRA1BAlpha-1B adrenergic receptorP35368
6ADRA1DAlpha-1D adrenergic receptorP25100
7ADRA2AAlpha-2A adrenergic receptorP08913
8ADRA2BAlpha-2B adrenergic receptorP18089
9ADRA2CAlpha-2C adrenergic receptorP18825
10ADRB1Beta-1 adrenergic receptorP08588
11ADRB2Beta-2 adrenergic receptorP07550
12CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha-1AO00555
13CACNA1BVoltage-dependent N-type calcium channel subunit alpha-1BQ00975
14CALCACalcitonin gene-related peptide 1P06881
15CHRM1Muscarinic acetylcholine receptor M1P11229
16CHRM2Muscarinic acetylcholine receptor M2P08172
17CHRM3Muscarinic acetylcholine receptor M3P20309
18CHRM4Muscarinic acetylcholine receptor M4P08173
19CHRM5Muscarinic acetylcholine receptor M5P08912
20DRD1Dopamine D1 receptorP21728
21DRD2D(2) dopamine receptorP14416
22DRD5D(1B) dopamine receptorP21918
23ESR1Estrogen receptorP03372
24GABRA2Gamma-aminobutyric-acid receptor alpha-2 subunitP47869
25GABRDGamma-aminobutyric acid receptor subunit deltaO14764
26GABRG3Gamma-aminobutyric acid receptor subunit gamma-3Q99928
27GRIN2BGlutamate ionotropic receptor NMDA type subunit 2BQ13224
28HRH1Histamine H1 receptorP35367
29HRH2Histamine H2 receptorP25021
30HTR1A5-Hydroxytryptamine receptor 1AP08908
31HTR2A5-Hydroxytryptamine 2A receptorP28223
32HTR2C5-Hydroxytryptamine 2C receptorP28335
33HTR75-Hydroxytryptamine receptor 7P34969
34KCNH2Potassium voltage-gated channel subfamily D member 2Q9NZV8
35MAOBAmine oxidase [flavin-containing] BP27338
36OPRD1Delta-type opioid receptorP41143
37OPRK1Opioid receptor kappa 1P41145
38OPRM1Opioid receptor mu 1P35372
39PTGS1Prostaglandin G/H synthase 1P23219
40PTGS2Prostaglandin G/H synthase 2P35354
41SCN10ASodium voltage-gated channel alpha subunit 10Q9Y5Y9
42SCN1ASodium voltage-gated channel alpha subunit 1P35498
43SLC6A2Sodium-dependent noradrenaline transporterP23975
44SLC6A3Sodium-dependent dopamine transporterQ01959
45SLC6A4Sodium-dependent serotonin transporterP31645
46TNFTumor necrosis factorP01375
47TRPM8Transient receptor potential cation channel subfamily M member 8Q7Z2W7
48TRPV1Transient receptor potential cation channel subfamily V member 1Q8NER1