Rhein Suppresses Neuroinflammation via Multiple Signaling Pathways in LPS-Stimulated BV2 Microglia Cells

Figure 4

Effects of Rhein on PI3K/Akt pathway components in LPS-stimulated BV2 cells. The cells were untreated (control) or pretreated with Rhein/DMSO for 30 min, followed by LPS stimulation (1 μg/mL) for 48 h. WB analysis was carried out to evaluate the protein levels of PI3K, p-PI3K, Akt, p-Akt, and PTEN. GAPDH as internal control. Data represent the mean ± SEM of three independent experiments. , , and .

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