Rhein Suppresses Neuroinflammation via Multiple Signaling Pathways in LPS-Stimulated BV2 Microglia Cells

Figure 5

Effects of Rhein on p38 and ERK1/2 pathway components in LPS-stimulated BV2 cells. The cells were untreated (control) or pretreated with Rhein/DMSO for 30 min, followed by LPS stimulation (1 μg/mL) for 48 h. WB analysis was carried out to evaluate the protein levels of p38, p-p38, ERK1/2, and p-ERK1/2. GAPDH as internal control. Data represent the mean ± SEM of three independent experiments. and .

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