Integrated Network and Experimental Pharmacology for Deciphering the Medicinal Substances and Multiple Mechanisms of Duhuo Jisheng Decoction in Osteoarthritis Therapy

Figure 6

Effects of DHJS on protein expression of NF-κB, p38, AMPK, SIRT1, Bax, Bcl2, and c-caspase3 in IL-1β-induced chondrocytes. DHJS reduced IL-1β-induced NF-κB phosphorylation (a). DHJS reduced IL-1β-induced p38 phosphorylation (b). DHJS increased AMPK phosphorylation and SIRT1 expression in IL-1β-induced chondrocytes (c). DHJS reduced Bax and c-caspase3 expression and increased Bcl2 expression in IL-1β-induced chondrocytes (d). Data are expressed as mean ± SD (n = 3). , , and , compared between the marked groups.

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