Integrated Network and Experimental Pharmacology for Deciphering the Medicinal Substances and Multiple Mechanisms of Duhuo Jisheng Decoction in Osteoarthritis Therapy

Table 1

Information for the ingredients of each herb in DHJS.

No.	Herb	Number of ingredients			Name of ingredients
		Total	OB & DL screening	Target screening
1	Duhuo	99	13	6	Ammidin, beta-sitosterol, columbianadin, marmesin, nodakenin, and osthol
2	Sangjisheng	46	4	3	Beta-sitosterol, oleanolic acid, and quercetin
3	Qinjiao	27		4	Beta-sitosterol, gentiopicrin, loganic acid, and oleanolic acid
4	Fangfeng	173	26	8	Ammidin, anomalin, beta-sitosterol, decursin, marmesin, phellopterin, prangenidin, and wogonin
5	Xixin	192	10	3	Asarinin, kaempferol, and sesamin
6	Rougui	100	3	3	Cinnamaldehyde, ethyl cinnamate, and procyanidin B1
7	Fuling	34	19	3	Hederagenin, pachymic acid, and poricoic acid A
8	Chuanxiong	189	12	4	Beta-sitosterol, ferulic acid, myricanone, and tetramethylpyrazine
9	Baishao	85	15	7	Albiflorin, beta-sitosterol, (+)-catechin, kaempferol, mairin, oleanolic acid, and paeoniflorin
10	Duzhong	147	39	13	Beta-carotene, beta-sitosterol, (+)-cycloolivil, cyclopamine, epicatechin, (+)-Eudesmin, kaempferol, mairin, (+)-medioresinol, pinoresinol diglucoside, quercetin, syringetin, and yangambin
11	Dangshen	134	26	6	Friedelin, glycitein, spinasterol, stigmasterol, tectorigenin, and luteolin
12	Gancao	280	101	28	Beta-sitosterol, calycosin, eurycarpin A, formononetin, glabridin, glabrone, glycyrol, glycyrrhizin, glypallichalcone, isolicoflavonol, isorhamnetin, jaranol, kaempferol, licochalcone A, licochalcone B, liquiritin, lupiwighteone, naringenin, oleanolic acid, pinocembrin, quercetin, and vestitol
13	Danggui	125	3	3	Beta-sitosterol, ferulic acid, and stigmasterol
14	Niuxi	176	22	15	Baicalin, baicalein, berberine, beta-ecdysterone, beta-sitosterol, coptisine, epiberberine, inophyllum E, kaempferol, oleanolic acid, palmatine, quercetin, spinasterol, stigmasterol, and wogonin
15	Shudihuang	76	6	3	Beta-sitosterol, stigmasterol, and verbascoside