Research Article
Hirudin Ameliorates Renal Interstitial Fibrosis via Regulating TGF-β1/Smad and NF-κB Signaling in UUO Rat Model
Figure 1
Effect of hirudin on kidney injury, body weight, serum Scr, and ALT level in UUO rats. (a) Kidney tissues collected in different groups. (b) Body weight among five groups. (c) HE (200×) and Masson (200×) staining of the experimental groups. (d) Kidney tubular injury score, based on HE staining. (e) Semiquantitative analysis of average optical density of fibrotic area, based on Masson staining. (f, g) Serum Scr and ALT level. Data are expressed as mean ± SD. For comparison among the UUO group and the control group, indicates . For comparison among the hirudin-treated groups and UUO group, indicates and indicates .
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