An Anti-Inflammatory Composition of Boswellia serrata Resin Extracts Alleviates Pain and Protects Cartilage in Monoiodoacetate-Induced Osteoarthritis in Rats

Figure 2

LI13019F1 downregulates inflammatory modulators in vitro. (a) The bar diagram presents a dose-dependent inhibition of 5-lipoxygenase enzyme activity by LI13019F1 in ferrous oxidation-xylenol orange (FOX) assay. (b) The line graphs show dose-dependent reductions of LTB₄ and PGE₂ productions in A23187-induced human polymorphonuclear neutrophils (PMNs) and LPS-induced human peripheral mononuclear cells (PBMCs), respectively. (c) The bar graph presents dose-dependent reductions of TNF-α production in LPS-induced human PBMC, as indicated. Data show mean ± SD; n = 3.

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(b)

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