Review Article

A Review of the Botany, Traditional Use, Phytochemistry, Analytical Methods, Pharmacological Effects, and Toxicity of Angelicae Pubescentis Radix

Table 1

The prescription composition, dosage form, and efficacy of AP.

Preparation nameMain compositionsAP dosageFormulationTraditional and clinical usesReference

Duhuo Jisheng Wan
Duhuo Jisheng Heji
Duhuo Jisheng Tang
Radix Angelicae Pubescentis54 gPill mixture decoctionNourish blood, relax tendon, dispel wind, eliminate dampness, and nourish liver and kidney. It is used to treat arthralgia and lumbago and knee pain.Chinese Pharmacopoeia
Taxilli Herba98 g
Rehmanniae Radix125 g
Achyranthis Bidentatae Radix
Asari Radix et Rhizoma
Gentianae Macrophyllae Radix
Poria
Cinnamomi Cortex
Saposhnikoviae Radix
Chuanxiong Rhizoma
Codonopsis Radix
Glycyrrhizae Radix et Rhizoma
Angelicae Sinensis Radix
Eucommiae Cortex
Paeoniae Radix Alba
Duhuo JiuRadix Angelicae Pubescentis200 gWineTreatment of rheumatic joint pain.Qianjinfang
Saposhnikoviae Radix
Typhonii Rhizoma
Duhuo Cangzhu TangRadix Angelicae PubescentisUnknownDecoctionDissipate cold, relieve pain.Zhengyinmaizhi
Atractylodis Rhizoma
Saposhnikoviae Radix
Asari Radix et Rhizoma
Chuanxiong Rhizoma
Duhuo TangRadix Angelicae Pubescentis25 gDecoctionTreatment of chronic limb pain.Huoyouxinshu
Angelicae Sinensis Radix
Atractylodis Macrocephalae Rhizoma
Astragali Radix
Achyranthis Bidentatae Radix
Duhuozi Tang
Yiwu Duhuo Tang
Duhuo Xixin Tang
Radix Angelicae Pubescentis500 gDecoctionTonify and replenish blood and kidney.Qianjinfang
Radix Angelicae Pubescentis150 gDecoctionTreatment of postpartum stroke.Xiaopinfang
Radix Angelicae PubescentisDecoctionTreat headaches caused by coldness.Zhengyinmaizhi
Asari Radix et Rhizoma
Chuanxiong Rhizoma
Gentianae Macrophyllae Radix
Rehmanniae Radix
Saposhnikoviae Radix
Duhuo SanRadix Angelicae Pubescentis50 gPulvisTreatment of all types of tumors.Pujifang
Scutellariae Radix
Angelicae Sinensis Radix
Chuanxiong Rhizoma
Rhei Radix et Rhizoma
Paeoniae Radix Rubra
Tianhe Zhuifeng GaoAsari Radix et RhizomaUnknownOintmentWarm channel and expelling cold, disperse wind and eliminate dampness, and activate blood and relieve pain. Used for joint pain and limb numbness caused by wind, cold, dampness, and blood stasis.Chinese Pharmacopoeia
Paeoniae Radix Alba
Radix Angelicae Pubescentis
Paeoniae Radix Rubra
Angelicae Sinensis Radix
Achyranthis Bidentatae Radix
Tianma WanGastrodiae Rhizoma50 gPillExpel wind and eliminate dampness, dredge collateral and relieve pain, tonify and replenish liver and kidney. Used for rheumatic stasis resulting in numbness of limbs and pain in waist and leg.Chinese Pharmacopoeia
Radix Angelicae Pubescentis
Achyranthis Bidentatae Radix
Rehmanniae Radix
Eucommiae Cortex
Angelicae Sinensis Radix
Tianma Qufeng BupianRehmanniae Radix50 gTabletWarm kidney nourishing the liver, dispel wind pain. Used for dizziness, tinnitus, joint pain, pain in waist and knee, and chills caused by liver and kidney loss, rheumatism and collateral penetration.Chinese Pharmacopoeia
Angelicae Sinensis Radix
Radix Angelicae Pubescentis
Eucommiae Cortex
Achyranthis Bidentatae Radix
Poria
Zhonghua Dieda WanRadix Angelicae Pubescentis76.8 gPillDetumescence and analgesia, relax tendons and activate collaterals, hemostatic myosheng, invigorate blood, and remove blood stasis. Used for bruising bones, old and new bruising, trauma bleeding, rheumatic bruising.Chinese Pharmacopoeia
Cyperi Rhizoma
Cinnamomi Ramulus
Achyranthis Bidentatae Radix
Eucommiae Cortex
Atractylodis Rhizoma
Zhengtian Wan Zhengtian JiaonangAngelicae Sinensis Radix102 gPill, capsuleExpel wind and activate blood, nourish blood and tonic liver, dredge collateral and relieve pain. It is used for migraines, tension headache, nerve headache, cervical spondylosis type headache, and premenstrual headache caused by external wind evil, blood stasis, blood loss of nutrition, hyperactivity of liver yang.Chinese Pharmacopoeia
Paeoniae Radix Alba
Saposhnikoviae Radix
Asari Radix et Rhizoma
Radix Angelicae Pubescentis
Ephedrae Herba
Zhuanggu Guanjie WanCibotii RhizomaUnknownPillTonify the liver and kidney, nourish blood and promote blood circulation, relax tendons and collaterals, regulate qi and relieve pain. Used for the treatment of arthritis, lumbar muscle strain, joint swelling, pain, numbness, limited movement.Chinese Pharmacopoeia
Radix Angelicae Pubescentis
Dipsaci Radix
Taxilli Herba
Rehmanniae Radix
Psoraleae Frsuctus
Wangbi Pian
Wangbi Keli
Rehmanniae RadixUnknownTabletTonify and replenish liver and kidney, strengthen tendons and bones. Disperse wind and dehumidification, dredge collateral and relax tendon. Used to treat rheumatoid arthritis.Chinese Pharmacopoeia
Dipsaci Radix
Radix Angelicae Pubescentis
Saposhnikoviae Radix
Rehmanniae Radix
Clematidis Radix et Rhizoma
Guogong JiuAngelicae Sinensis RadixUnknownWineDisperse wind and dehumidification, relax sinew and dredge collateral. Used for the treatment of joint pain, adverse flexion and extension, hand and foot numbness, pain in waist and leg. It is also used for hemiplegia and askew caused by imbalance between channels and collaterals.Chinese Pharmacopoeia
Achyranthis Bidentatae Radix
Radix Angelicae Pubescentis
Paeoniae Radix Alba
Psoraleae Fructus
Saposhnikoviae Radix
Baidu SanCodonopsis Radix100 gPulvisRelieving exterior syndrome by diaphoresis, disperse wind and dehumidification. Used to treat fever, headache, sore limbs, stuffy nose, cough and phlegm.Chinese Pharmacopoeia
Aurantii Fructus
Chuanxiong Rhizoma
Radix Angelicae Pubescentis
Peucedani Radix
Bupleuri Radix
Goupi GaoSaposhnikoviae Radix20 gOintmentDisperse wind and dissipate cold, activate blood and relieve pain. Used for the treatment of limb numbness, lumbago and leg pain, or bruise injury, local swelling and pain.Chinese Pharmacopoeia
Ephedrae Herba
Angelicae Sinensis Radix
Dipsaci Radix
Paeoniae Radix Alba
Radix Angelicae Pubescentis
Fufang Xiatianwu PianAGKISTRODONUnknownTabletDisperse wind and dehumidification, relax the tendons and collaterals, blood circulation and pain. It is used for the treatment of joint swelling pain, limb numbness, adverse flexion and rheumatoid arthritis, sciatica caused by obstruction of meridians and collaterals and rheumatic stasis block, sequelae of cerebral thrombosis and poliomyelitis.Chinese Pharmacopoeia
Radix Angelicae Pubescentis
Clematidis Radix et Rhizoma
Salviae Miltiorrhizae Radix et Rhizoma
Achyranthis Bidentatae Radix
Huoxue Zhitong GaoPaeoniae Radix Alba5.4 gOintmentActivate blood and relieve the pain. Used for the treatment of muscle and bone pain, muscle paralysis, resolve phlegm, joint pain.Chinese Pharmacopoeia
Citri Reticulatae Pericarpium
Angelicae Sinensis Radix
Asari Radix et Rhizoma
Schizonepetae Herba
Radix Angelicae Pubescentis
Qufeng Zhitong Wan
Qufeng Zhitong Pian
Qufeng Zhitong
Jiaonang
Dipsaci Radix83 gPill, tablet, capsuleDisperse wind and dehumidification, tonify and replenish liver and kidney, strengthening tendons and bones used for the treatment of joint swelling, lumbago and knee pain, limb numbness.Chinese Pharmacopoeia
Clematidis Radix et Rhizoma
Radix Angelicae Pubescentis
Tongbi JiaonangAstragali Radix4.42 gCapsuleDisperse wind and dehumidification, activate blood and dredge collateral, dissipate cold and relieve pain, nourish and activate blood. Used for the treatment of cold joint pain, flexion and extension, rheumatoid arthritis.Chinese Pharmacopoeia
Angelicae Sinensis Radix
Radix Angelicae Pubescentis
Saposhnikoviae Radix
Typhonii Rhizoma
Corydalis Rhizoma
Jisheng Zhuifeng JiuRadix Angelicae PubescentisUnknownWineTonify and replenish liver and kidney, disperse wind and dehumidification, relieve pain. For the treatment of liver and kidney two deficient, wind cold dampness bi, waist and knee cold pain, flexion and extension, rheumatoid arthritis, lumbar muscle strain, injury.Chinese Pharmacopoeia
Achyranthis Bidentatae Radix
Saposhnikoviae Radix
Asari Radix et Rhizoma
Angelicae Sinensis Radix
Poria
Shujin WanStrychni Semen6 gPillDisperse wind and dehumidification, relax tendon and activate blood. For the treatment of wind, cold and dampness, numbness of limbs, muscle and bone pain, walking difficult.Chinese Pharmacopoeia
Ephedrae Herba
Radix Angelicae Pubescentis
Saposhnikoviae Radix
Eucommiae Cortex
Dipsaci Radix
Shujin Huoluo JiuTaxilli Herba30 gWineDisperse wind and dehumidification, activate blood and dredge collateral, tonify yin and promote fluid production. Used for adverse flexion and extension, limb numbness, joint pain caused by yin deficiency, rheumatism blocking collateral, blood stasis.Chinese Pharmacopoeia
Achyranthis Bidentatae Radix
Angelicae Sinensis Radix
Chuanxiong Rhizoma
Radix Angelicae Pubescentis
Saposhnikoviae Radix
Shufeng Dingtong WanStrychni Semen30 gPillDisperse wind and dissipate cold, activate blood and relieve pain. Used for joint pain, cold pain, stabbing pain, waist and leg pain and limb numbness caused by wind, cold and wet closure, and blood stasis. Local swelling caused by a bruise.Chinese Pharmacopoeia
Achyranthis Bidentatae Radix
Saposhnikoviae Radix
Radix Angelicae Pubescentis
Ephedrae Herba
Eucommiae cortex
Yaobitong JiaonangNotoginseng Radix et RhizomaUnknownCapsuleActivate blood and resolve stasis, dispel wind and eliminate dampness, move qi and stop pain. Used for lumbago caused by blood stasis and qi stagnation.Chinese Pharmacopoeia
Chuanxiong Rhizoma
Corydalis Rhizoma
Paeoniae Radix Alba
Achyranthis Bidentatae Radix
Radix Angelicae Pubescentis
Shexiang Qutong
Qiwuji
Shexiang Qutong Chaji
Moschus1 gAerosol linimentActivate blood and resolve stasis, relax sinew and activate collateral, eliminate swelling and relieve pain. Used for all kinds of fall injury, blood stasis swelling pain, rheumatism stasis, joint pain.Chinese Pharmacopoeia
Carthami Flos
Radix Angelicae Pubescentis
Rehmanniae Radix
Notoginseng Radix et Rhizoma