Jieyu Anshen Granule, a Chinese Herbal Formulation, Exerts Effects on Poststroke Depression in Rats

Table 2

Effect of JY on levels of NE, DA, and 5-HT in the prefrontal cortex, hippocampus, hypothalamus, and striatum of PSD rats; μg/g tissue.

Brain area	Groups	NE	DA	5-HT
Prefrontal cortex	CON	42.96 ± 3.39	8.54 ± 1.57	0.58 ± 0.06
	MCAO + CUMS	31.84 ± 5.60	4.98 ± 0.51^##	0.43 ± 0.03^##
	CIT10	35.30 ± 2.35	6.15 ± 1.17	0.56 ± 0.06
	JY1	36.01 ± 3.64	5.94 ± 0.63	0.56 ± 0.05
Hippocampus	CON	31.90 ± 4.74	8.61 ± 0.65	0.70 ± 0.09
	MCAO + CUMS	23.05 ± 4.09^#	6.53 ± 0.30^##	0.51 ± 0.11^#
	CIT10	25.71 ± 8.01	7.50 ± 1.03	0.67 ± 0.05
	JY1	30.63 ± 5.03	7.44 ± 0.50	0.68 ± 0.06
Hypothalamus	CON	42.54 ± 2.44	7.16 ± 0.46	0.50 ± 0.07
	MCAO + CUMS	31.63 ± 4.83^##	5.54 ± 0.62^##	0.38 ± 0.04^##
	CIT10	39.79 ± 3.58	6.73 ± 0.77	0.45 ± 0.03
	JY1	40.07 ± 1.62	6.72 ± 1.22	0.44 ± 0.03
Striatum	CON	51.88 ± 8.41	9.96 ± 1.58	0.70 ± 0.12
	MCAO + CUMS	40.79 ± 8.17^#	8.00 ± 0.84^#	0.58 ± 0.08^#
	CIT10	50.86 ± 7.25	9.66 ± 2.17	0.60 ± 0.16
	JY1	51.51 ± 4.97	8.33 ± 1.17	0.64 ± 0.14

Data are expressed as mean ± SEM. n = 7–10. compared to CON group. compared to MCAO + CUMS group.