Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation

Figure 1

Differential methylation study of bone marrow samples from 5 MDS patients before treatment versus those from 3 healthy individuals. (a) Heatmap representing a supervised cluster centered on the median of the methylation levels between 5 MDS patients before treatment (TP_before) and 3 healthy individuals. Samples are represented as TP_before (salmon orange) and control (turquoise). Hypermethylated site probes in MDS patients are represented in orange, and hypomethylated probes are represented in blue. (b) Volcano plot representation of the methylation of significant gene sites. Hypomethylated probes are represented in green colour, and hypermethylated probes are represented in red. Red lines delineate ±0.1 methylation differences between the MDS patients and healthy donors and the dotted line represents a value threshold of 0.05. (c) Significantly changed GO terms for hypomethylated genes in the MDS patients. The y axis shows the category and the x axis shows the –LgP. The larger –LgP indicated a smaller value.

(a)

(b)

(c)