Traditional Chinese Medicine Containing Arsenic Treated MDS Patients Effectively through Regulating Aberrant Hypomethylation

Figure 3

Changes in the DNA methylation status in 5 MDS patients after treatment by the Human Methylation 850K BeadChip. (a) Volcano plot representation of the methylation of significant gene sites. Hypomethylated probes are represented in green colour and hypermethylated probes are represented in red. Red lines delineate ±0.1 methylation differences between the MDS patients after treatment and the MDS patients before treatment, and the dotted line represents a value threshold of 0.05. (b) Distribution of differentially methylated sites in the chromosomes of the MDS patients: red represents hypermethylated sites and green represents hypomethylated sites. (c) Significantly changed GO terms for hypermethylated genes induced by CM treatment. The y axis shows category, and the x axis shows –LgP. The larger –LgP indicated a smaller value.

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