Antioxidant Effect of Standardized Extract of Propolis (EPP-AF®) in Healthy Volunteers: A “Before and After” Clinical Study

Table 3

Urinary excretion of 8-isoprostanes (ng/mg de creatinine) and 8-OHDG (ng/mg de creatinine) and MDA plasma concentration (μmol/L) before (baseline) and after oral use of EPP-AF® (375 and 750 mg/d) in health volunteers. Values are expressed as mean and confidence interval of 95% (CI 95%).

	Baseline	EPP-AF 375 mg		EPP-AF 750 mg
8-ISO (ng/mg de creatinine)	1.1 (0.9–1.3)	0.85 (0.75–0.95)	0.01	0.89 (0.74–1.0)	0.03
8-OHDG (ng/mg de creatinine)	15.7 (13.2–18.1)	13.9 (12.2–15.6)	0.16	11.6 (10.2–13.0)	0.004
MDA (μmol/L)	2.9 (2.3–3.4)	2.6 (2.2–2.9)	0.22	3.3 (2.8–3.9)	0.06

P value compared with baseline.