Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation

Figure 2

MV improved hepatic steatosis through inhibiting lipogenesis and promoting fatty acid oxidation and lipolysis in HFD-fed C57BL/6 mice. Representative immunoblot detection of FASN (a), SREBP-1 (b), PPAR-γ (c), PPAR-α (d), and CPT-1A (e) protein expression. (f) The mRNA expression of lipogenesis-relative genes including fasn, srebp1, pparg, and scd1. (g) The mRNA expressions of ppara, cpt1a, hsl, and atgl in the liver tissues of HFD-fed mice. Data are presented as mean ± SEM (n = 3-4). vs. control; vs. control; vs. control; vs. HFD; vs. HFD.

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