Advances in Research on the circRNA-miRNA-mRNA Network in Coronary Heart Disease Treated with Traditional Chinese Medicine

Figure 1

The potential role of the circRNA-miRNA-mRNA regulatory network in the cardiovascular diseases treated with TCM CDIP1: cell death-inducing protein 1; Smad3: recombinant human mothers against decapentaplegic homolog 3; CTGF: connective tissue growth factor; MAPK: mitogen-activated protein kinase; ERK1/2: extracellular signal regulated kinases 1 and 2; ARC: recombinant activity regulated cytoskeleton associated protein; PPRs: pentatricopeptide repeat proteins; CaMKIIδ: calmodulin-dependent protein kinase IIδ; GSK3β: glycogen synthase kinase-3β; eNOS: endothelial nitric oxide synthase; NCX1: sodium/calcium exchanger 1; BIM: BCL2-like 11; a-SMA: anti-α smooth muscle actin; COL1A1: recombinant collagen type I alpha 1; COL3A1: recombinant collagen type III alpha 1; MMP: mitochondrial membrane potential; TIMP: tissue inhibitor of metalloproteinase; IGF-1: insulin-like growth factor-1; and VEGFA: vascular endothelial cells growth factor A.