Advances in Research on the circRNA-miRNA-mRNA Network in Coronary Heart Disease Treated with Traditional Chinese Medicine

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left">VSMCs</td><td class="align_center">Endothelial cells</td><td class="align_center">Cardiomyocytes</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">Inhibiting expression or activity of contractile and structural proteins</td><td class="align_center">Activation of NO signaling pathway</td><td class="align_center">Alleviation of cardiac hypertrophy</td></tr><tr><td class="align_left">Regulating expression of extracellular matrix proteins</td><td class="align_center">Inhibition of inflammation</td><td class="align_center">Attenuation of oxidative stress</td></tr><tr><td class="align_left">Regulating calcium levels in a PKA/PKG/PKC-dependent way</td><td class="align_center">Attenuation of oxidative stress</td><td class="align_center">Inhibition of apoptosis</td></tr><tr><td class="align_left">Attenuating proliferation and migration of VSMCs</td><td class="align_center">Inhibition of apoptosis,</td><td class="align_center">Opening K<sub>ATP</sub> channels</td></tr><tr><td class="align_left">Anti-inflammation improving mitochondrial function</td><td class="align_center">Inducing angiogenesis suppression of endothelial permeability</td><td class="align_center">ANP secretion</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>The pharmacological mechanisms of CHM.</div>

Evidence-Based Complementary and Alternative Medicine

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Table 2

Table 2: Advances in Research on the circRNA-miRNA-mRNA Network in Coronary Heart Disease Treated with Traditional Chinese Medicine 