Sikyungbanha-Tang Suppressing Acute Lung Injury in Mice Is Related to the Activation of Nrf2 and TNFAIP3

Figure 6

Schematics of proposed mechanisms of SKBHT. When administered to the inflamed mouse lungs, SKBHT could suppress inflammatory reactions in the lungs. Since SKBHT activated Nrf2 and TNFAIP3, which resulted in suppressing NF-κB, in RAW 264.7 cells, we propose that activation of Nrf2 and TNFAIP3 collectively contributes to the suppression of lung inflammation by SKBHT.